Antioxidant Therapy linked to telomerase production and heart failure treatment

Posted by: on Feb 6, 2012 | No Comments

A study conducted by the Department of Molecular and Cellular Biology at  Kyushu University’s Medical Institute of Bioregulation in Beppu, Japan has connected oxidative stress and the development of heart failure to telomeres and telomerase activity.

In the study, mice with deficient heart muscles which made them susceptible to congestive heart failure were administered with oxidative stress for four weeks. At the end of this time, their telomere lengths and telomerase activity was compared with that of other control mice. Results showed that telomerase activity was decreased in heart tissue from the mice administered with the oxidative stress, compared to the control mice.

These results show that oxidant stress may affect telomerase activity and telomere-associated proteins negatively, which therefore means that antioxidant therapy may help in treating human heart failure by lengthening telomeres and increasing telomerase production.