Youth Restoring Benefits Of NAD+

Posted by: on Feb 12, 2015 | No Comments

NAD+Normal aging is accompanied by a noticeable increase in fatigue and loss of motivation. The tiredness we outwardly feel reflects inward impairment of cellular functions critical to sustaining life. NAD+ is the term used in the scientific literature to describe a cellular compound called nicotinamide adenine dinucleotide.

NAD+ is found in every cell in the body and is essential to life. NAD+ enables the transfer of energy from the foods we eat to vital cell functions. It is also required to “turn off” genes that accelerate degenerative aging processes. As NAD+ levels decline, mitochondrial function is impaired, resulting in fewer mitochondria surviving. This vicious cycle of mitochondrial depletion results in many of the physical symptoms of aging.

Now, Researchers have discovered a form of vitamin B3 that converts in the body to NAD+.
Vitamin B3 is involved in over 400 enzymatic reactions throughout the body and is essential for production and management of cellular energy. A new patented form of this vitamin called nicotinamide riboside has been found to increase NAD+ levels and in the process, provide an extraordinary range of longevity benefits that promises to change how we combat aging.

Studies have shown that nicotinamide riboside switches “off” the genes of aging, extends life span, increases endurance, improves cognitive function, activates sirtuins, and enhances cellular energy. These benefits add up to a system-wide slowing and reversal of certain aging processes. Nicotinamide riboside accomplishes this NAD+ boosting effect without the irritating skin flushing and rash caused by the standard forms of vitamin B3.

In their investigations into the effects of nicotinamide riboside on life span, scientists used a strain of yeast known to have a relatively short average life span of about 8.3 generations. When the yeast was treated with nicotinamide riboside, the average life span nearly doubled, to 16.1 generations. On this model of life span extension, ordinary vitamin B3 had no effect compared to the dramatic longevity benefit shown with nicotinamide riboside.

When pursuing additional lab studies, scientists found that supplementing mice with nicotinamide riboside reduced many dangerous factors of aging. The mice showed increased energy and improved insulin sensitivity, both factors indicating optimal vitality. In this study, scientists also demonstrated that nicotinamide riboside supplementation increased energy metabolism while protecting the animals against the metabolic abnormalities induced by a high-fat diet. For the study, the mice were fed a high-fat diet with either no supplementation (control), or nicotinamide riboside for 12 or 16 weeks.

On a treadmill test, the supplemented animals fed a high-fat diet ran more than 33% further than the control mice, demonstrating a dramatic increase in muscle endurance and performance.

The supplemented mice also gained significantly less weight while on the high-fat diet compared to control animals. And in supplemented animals fed either the high-fat or a normal diet, insulin sensitivity (the ability to remove sugar efficiently from the blood) was greatly improved, compared with control animals.

Detailed analysis of the mice in this study revealed that supplementation with nicotinamide riboside had produced a significant increase in essential NAD+ levels, resulting in the activation of the critical life span-extending enzymes SIRT1 and SIRT3. Supplementation with nicotinamide riboside also improved the numbers and function of mitochondria, the intracellular powerhouses that release energy from food; poor mitochondrial function is a known age-accelerator.

SIRT enzymes regulate how genes are expressed from the DNA on our chromosomes in part by influencing chromosomal proteins called histones. Research indicates SIRT enzymes have a “slot” capable of binding to one NAD+ molecule and one chemical acetyl (AC) group from the histone. This binding triggers the SIRT enzyme to remove the acetyl group and bind the histone proteins more closely to their DNA strands, thereby regulating the expression of genes.

So, just as a coin in a parking meter slot adds time to the meter with each turn of the handle, a NAD+ molecule binding to a SIRT enzyme, with each “turn” of the enzymatic cycle, manipulates DNA expression in a way that adds time to one’s life.

A recent lab study also demonstrated the ability of nicotinamide riboside to protect brain cells in advanced age. For the study, mice engineered to develop Alzheimer’s disease were treated with nicotinamide riboside beginning at middle age (5 to 6 months) and lasting into old age (10 to 11 months).

The supplemented animals had significant improvements in their cognitive function in challenging laboratory tests of exploring new objects. This improvement was shown to be associated with significantly reduced brain levels of beta-amyloid plaques, the abnormal protein that triggers much of the neuronal death and dysfunction in Alzheimer’s disease.

Although evidence for life expectancy benefit is indirect, the combination of sirtuin activation and NAD+ intermediate supplementation may be an effective anti-aging intervention, providing hope to aging societies worldwide.

For more information, also see The Anti-Aging Pill